Search results for "sequential treatment"

showing 3 items of 3 documents

Sequential treatment of ADHD in mother and child (AIMAC study): importance of the treatment phases for intervention success in a randomized trial

2018

Abstract Background The efficacy of parent-child training (PCT) regarding child symptoms may be reduced if the mother has attention-deficit/hyperactivity disorder (ADHD). The AIMAC study (ADHD in Mothers and Children) aimed to compensate for the deteriorating effect of parental psychopathology by treating the mother (Step 1) before the beginning of PCT (Step 2). This secondary analysis was particularly concerned with the additional effect of the Step 2 PCT on child symptoms after the Step 1 treatment. Methods The analysis included 143 mothers and children (aged 6–12 years) both diagnosed with ADHD. The study design was a two-stage, two-arm parallel group trial (Step 1 treatment group [TG]: …

AdultMalePediatricsmedicine.medical_specialtyEfficacylcsh:RC435-571610Motherslaw.inventionTreatment and control groups03 medical and health sciences0302 clinical medicinePharmacotherapy610 Medical sciences MedicineRandomized controlled trialChild of Impaired ParentslawIntervention (counseling)lcsh:PsychiatryMedicineHumans0501 psychology and cognitive sciencesddc:610ChildChildrenProblem BehaviorPsychiatric Status Rating ScalesPsychotropic Drugsbusiness.industryParent training05 social sciencesTreatment phasesAdult treatmentSequential treatmentCombined Modality Therapy3. Good healthPsychotherapyPsychiatry and Mental healthTreatment OutcomeAttention Deficit Disorder with HyperactivityParent trainingParental psychopathologyFemalebusiness030217 neurology & neurosurgery050104 developmental & child psychologyResearch Article
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First-Line Immune Checkpoint Inhibitor-Based Sequential Therapies for Advanced Hepatocellular Carcinoma: Rationale for Future Trials

2021

<b><i>Introduction:</i></b> Atezolizumab (ATEZO) plus bevacizumab (BEVA) represents the new standard of care for the treatment of advanced hepatocellular carcinoma (HCC). However, the choice of the second-line treatment after the failure of immunotherapy-based first-line remains elusive. Taking into account the weaknesses of the available evidence, we developed a simulation model based on available phase III randomized clinical trials (RCTs) to identify optimal risk/benefit sequential strategies. <b><i>Methods:</i></b> A Markov model was built to estimate the overall survival (OS) of sequential first- and second-line systemic treatments. Seque…

Hepatologybusiness.industryImmune checkpoint inhibitorsFirst lineNeoplasms. Tumors. Oncology. Including cancer and carcinogenshepatocellular carcinomamedicine.diseaseOncologysequential treatmentHepatocellular carcinomaCancer researchMedicineimmunotherapybusinessRC254-282Research Article
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ChemInform Abstract: Tandem Asymmetric Michael Reaction-Intramolecular Michael Addition. An Easy Entry to Chiral Fluorinated 1,4-Dihydropyridines.

2010

The sequential treatment of optically active sulfoxide (I) with fluorinated nitriles and alkyl propiolates affords (sulfinylmethyl)dihydropyridines of type (IV) as single diastereomers in most cases.

chemistry.chemical_classificationchemistry.chemical_compoundTandemchemistryIntramolecular forceMichael reactionDiastereomerSulfoxideGeneral MedicineOptically activeMedicinal chemistrySequential treatmentAlkylChemInform
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